- Abuse Hotline 1-800-252-5400
- Adopt America 1-800-385-6301
- Adoption Afiliates 1-800-270-6757
- Alcohol Abuse 24-hour Hotline 1-800-258-7780
- Alcoholics Anonymous 513 N. Bedell Ave. (830) 775-7008
- Alcohol - Drug Treatment Referral 1-800-454-8966
- American Red Cross 127 Foster Dr. (830) 775-8626
- Amistad Family Violence & Rape Crisis Center 100 Center Dr. (830) 775-9612
- Amistad Pregnancy Care 105 Fletcher Dr. Rear (830) 775-8076
- Baptist Child & Family Services 310 Margaret Ln. (830) 768-2755
- Charter Real Mental Health Services of Del Rio 501 Cantu Rd. (830) 774-4265
- Christian Alcohol and Drug Treatment Referral 1-800-952-7391
- Consumer Credit Counseling Service 1-210-979-4411
- Counseling Center 1004 E. 9th St. (830) 774-0886
- National Center for Missing and Exploited Children 1-800-843-5678
- National Response Center Report Chemical/Oil Spills and Chemical/Biological Terrorism 1-800-424-8802
- Poison Control Center 1-800-222-1222
- Quad Counties Council-Alcohol 902 S. Main St. #C (830) 774-7411
- Suicide Prevention Hotline 1-800-784-2433
- Texas Department of Public Safety Roadway Emergencies 1-800-525-5555
- Texas Runaway Hotline 1-800-580-4357
- Texas Youth Hotline 1-800-210-2278
- Treatment Associates 902 S. Main St. (830) 778-2099
- Vanished Children's Alliance 24-Hour Sighting Hotline 1-800-826-4743
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